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1

Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase

Gaillard, Pascale, Jeanclaude-Etter, Isabelle, Ardissone, Vittoria, Arkinstall, Steve, Cambet, Yves, Camps, Montserrat, Chabert, Christian, Church, Dennis, Cirillo, Rocco, Gretener, Denise, Halazy, Se

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 209 KB

english, 2005

2

ChemInform Abstract: Synthesis of Arylpiperazines via Nucleophilic Aromatic Substitution of (η6-Fluoroarene)tricarbonylchromium Complexes.

M. PEREZ, P. POTIER, S. HALAZY

Journal:

Année:

1997

Fichier:

PDF, 33 KB

1997

3

ChemInform Abstract: Design and Synthesis of New Potential Photoaffinity Labels for Mammalian Squalene Epoxidase.

J.-P. GOTTELAND, C. DAX, S. HALAZY

Journal:

Année:

1997

Fichier:

PDF, 31 KB

1997

4

ChemInform Abstract: Arylpiperazide Derivatives of Phenylpiperazines as a New Class of Potent and Selective 5-HT1B Receptor Antagonists.

C. JORAND-LEBRUN, P. J. PAUWELS, C. PALMIER, P. CHOPIN, C. MORET, M. MARIEN, S. HALAZY

Journal:

Année:

1998

Fichier:

PDF, 35 KB

1998

5

ChemInform Abstract: Dimerization of Sumatriptan as an Efficient Way to Design a Potent, Centrally and Orally Active 5-HT1B Agonist.

M. PEREZ, P. J. PAUWELS, C. FOURRIER, P. CHOPIN, J.-P. VALENTIN, G. W. JOHN, M. MARIEN, S. HALAZY

Journal:

Année:

1998

Fichier:

PDF, 35 KB

1998

6

ChemInform Abstract: Use of Triphosgene for Direct Preparation of Carbamoyl Chlorides from Tertiary Benzylamines.

C. JORAND-LEBRUN, D. VALOGNES, S. HALAZY

Journal:

Année:

1998

Fichier:

PDF, 28 KB

1998

7

ChemInform Abstract: Sulfonamide Derivatives of Benzylamine Block Cholesterol Biosynthesis in HepG2 Cells: A New Type of Potent Squalene Epoxidase Inhibitors.

J.-P. GOTTELAND, C. LOUBAT, B. PLANTY, D. JUNQUERO, A. DELHON, S. HALAZY

Journal:

Année:

1998

Fichier:

PDF, 36 KB

1998

8

ChemInform Abstract: Design and Synthesis of New Potent, Silent 5-HT1A Antagonists by Covalent Coupling of Aminopropanol Derivatives with Selective Serotonin Reuptake Inhibitors.

M. Perez, P. J. Pauwels, I. Pallard-Sigogneau, C. Fourrier, P. Chopin, C. Palmier, V. Colovray, S. Halazy

Journal:

Année:

1999

Fichier:

PDF, 32 KB

1999

9

Fluorophosphonate derivatives of N9-benzylguanine as potent, slow-binding multisubstrate analogue inhibitors of purine nucleoside phosphorylase

S. Halazy, A. Ehrhard, A. Eggenspiller, V. Berges-Gross, C. Danzin

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 494 KB

english, 1996

10

Synthesis of new carbocyclic phosphonate analogs of dideoxypurine nucleotides

D. Wolff-Kugel, S. Halazy

Journal:

Tetrahedron Letters

Année:

1991

Langue:

english

Fichier:

PDF, 245 KB

english, 1991

11

Synthesis of arylpiperazines via nucleophilic aromatic substitution of (η6-fluoroarene)tricarbonylchromium complexes

Michel Perez, Pierre Potier, Serge Halazy

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 112 KB

english, 1996

12

5-O-Carboxymethyl piperazide derivatives of serotonin: a new class of potent and selective 5-HT1D receptor agonists

Michel Perez, Petrus Pauwels, Christiane Palmier, Gareth W. John, Jean-Pierre Valentin, Serge Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 234 KB

english, 1995

13

Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

Jean-François Navé, Patrick J. Casara, Debra L. Taylor, A. Stanley Tyms, Michael Kenny, Serge HalazyS

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 286 KB

english, 1996

14

Design and synthesis of new hypocholesterolemic organosilanes with antioxidant properties

J.-P. Gotteland, A. Delhon, D. Junquéro, P. Oms, S. Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 298 KB

english, 1996

15

Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine

M. Lamothe, D. Perrin, D. Blotières, M. Leborgne, S. Gras, D. Bonnet, B.T. Hill, S. Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 325 KB

english, 1996

16

Synthesis and evaluation of new 6-deoxy-6-fluorinated glucosides as inhibitors of yeast α-glucosidase

Serge Halazy, Véronique Berges, Anne Ehrhard, Charles Danzin

Journal:

Journal of Fluorine Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 564 KB

english, 1992

17

Efficient regioselective syntheses of α and β cuparenones. A new approach for the construction of the cyclopentane ring

S. Halazy, F. Zutterman, A. Krief

Journal:

Tetrahedron Letters

Année:

1982

Langue:

english

Fichier:

PDF, 238 KB

english, 1982

18

Allylselenides possessing a terminal double bond first regioselective synthesis and reactions

T. Di Giamberardino, S. Halazy, W. Dumont, A. Krief

Journal:

Tetrahedron Letters

Année:

1983

Langue:

english

Fichier:

PDF, 181 KB

english, 1983

19

New rearrangement of the adducts formed from allenes and benzeneselenenyl halides

S Halazy, L Hevesi

Journal:

Tetrahedron Letters

Année:

1983

Langue:

english

Fichier:

PDF, 216 KB

english, 1983

20

α-Selenocyclobutyllithium as a 2-lithio-1,3-diene equivalent. regioselective (100%) synthesis of ipsenol

S. Halazy, A. Krief

Journal:

Tetrahedron Letters

Année:

1980

Langue:

english

Fichier:

PDF, 168 KB

english, 1980

21

Studies on the antitumor agent CC-1065 : Regiospecific introduction of the oxygen functionality for the synthesis of the B/C component of CC-1065.

Philip Magnus, Serge Halazy

Journal:

Tetrahedron Letters

Année:

1985

Langue:

english

Fichier:

PDF, 183 KB

english, 1985

22

Studies on the antitumor agent CC-1065 : 1-Phenylsulfonyl-1,3-butadiene. An electrophilic equivalent to 1,3-butadiene for the synthesis of 3,31-bipyrroles.

Serge Halazy, Philip Magnus

Journal:

Tetrahedron Letters

Année:

1984

Langue:

english

Fichier:

PDF, 184 KB

english, 1984

23

New reactions of 1-seleno-1-vinyl cyclopropanes

S. Halazy, A. Krief

Journal:

Tetrahedron Letters

Année:

1981

Langue:

english

Fichier:

PDF, 194 KB

english, 1981

24

Synthesis and reactivity of α-lithio α-trimethylsilyl cyclopropanes and related derivatives

S. Halazy, W. Dumont, A. Krief

Journal:

Tetrahedron Letters

Année:

1981

Langue:

english

Fichier:

PDF, 232 KB

english, 1981

25

Regio and stereoselective synthesis of 1-methylseleno-1-vinyl and 1-phenylseleno-1-vinyl cyclopropanes

S. Halazy, A. Krief

Journal:

Tetrahedron Letters

Année:

1981

Langue:

english

Fichier:

PDF, 204 KB

english, 1981

26

Synthesis of 1-phenylseleno-1-vinyl and 1-methylseleno-1-vinyl cyclopropanes by formal dehydration of β-hydroxycyclopropyl selenides

S. Halazy, A. Krief

Journal:

Tetrahedron Letters

Année:

1981

Langue:

english

Fichier:

PDF, 178 KB

english, 1981

27

Synthetic routes to cyclopropylidenecarbinols and to cyclopropylidienes

S. Halazy, A. Krief

Journal:

Tetrahedron Letters

Année:

1981

Langue:

english

Fichier:

PDF, 197 KB

english, 1981

28

Cyclopropanone diselenoketals interesting building blocks in organic synthesis

S. Halazy, J. Lucchetti, A. Krief

Journal:

Tetrahedron Letters

Année:

1978

Langue:

english

Fichier:

PDF, 222 KB

english, 1978

29

Synthesis, binding affinity and intrinsic activity of new anilide derivatives of serotonin at human 5-HT1D receptors

M Perez, N Ayerbe, C Fourrier, I Sigogneau, PJ Pauwels, C Palmier, GW John, JP Valentin, S Halazy

Journal:

European Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 714 KB

english, 1997

30

Phosphonate derivatives of N9-benzylguanine: a new class of potent purine nucleoside phosphorylase inhibitors

Serge Halazy, Anne Eggenspiller, Anne Ehrhard, Charles Danzin

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 312 KB

english, 1992

31

Carbocyclic phosphonate analogs of 2′,3′-dideoxyadenosine-5′-monophosphate as substrates of 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetate

Jean-François Navé, Dominique Wolff-Kugel, Serge Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 390 KB

english, 1992

32

Design and synthesis of new potential photoaffinity labels for mammalian squalene epoxidase

J.-P. Gotteland, C. Dax, S. Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 215 KB

english, 1997

33

Arylpiperazide derivatives of phenylpiperazines as a new class of potent and selective 5-HT1B receptor antagonists

C. Jorand-Lebrun, P.J. Pauwels, C. Palmier, P. Chopin, C. Moret, M. Marien, S. Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 329 KB

english, 1997

34

Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist

Michel Perez, Petrus J. Pauwels, Catherine Fourrier, Philippe Chopin, Jean-Pierre Valentin, Gareth W. John, M. Marien, Serge Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 402 KB

english, 1998

35

Dimers of 5HT1 ligands preferentially bind to 5HT1b1d receptor subtypes

Michel Perez, Catherine Jorand-Lebrun, Petrus J. Pauwels, Isabelle Pallard, Serge Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 318 KB

english, 1998

36

Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: A new type of potent squalene epoxidase inhibitors

J.-P. Gotteland, C. Loubat, B. Planty, D. Junquéro, A. Delhon, S. Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 264 KB

english, 1998

37

Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors

M Perez, P.J Pauwels, I Pallard-Sigogneau, C Fourrier, P Chopin, C Palmier, V Colovray, S Halazy

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 323 KB

english, 1998

38

Dimerization of 8-OH-DPAT increases activity at serotonin 5-HT1A receptors

P. J. Pauwels, Delphine S. Dupuis, Michel Perez, Serge Halazy

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 124 KB

english, 1998

39

Ortho- and para-(difluoromethyl)aryl-β-d-glucosides: A new class of enzyme-activated irreversible inhibitors of β-glucosidases

S. Halazy, V. Berges, A. Ehrhard, C. Danzin

Journal:

Bioorganic Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 765 KB

english, 1990

40

A new general route to olefins from selenides

S. Halazy, A. Krief

Journal:

Tetrahedron Letters

Année:

1979

Langue:

english

Fichier:

PDF, 258 KB

english, 1979

41

Discovery and Development of a New Class of Potent, Selective, Orally Active Oxytocin Receptor Antagonists

Quattropani, Anna, Dorbais, Jérôme, Covini, David, Pittet, Pierre-André, Colovray, Véronique, Thomas, Russell J., Coxhead, Richard, Halazy, Serge, Scheer, Alexander, Missotten, Marc

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 444 KB

english, 2005

42

ChemInform Abstract: (Aryloxy)methylsilane Derivatives as New Cholesterol Biosynthesis Inhibitors: Synthesis and Hypocholesterolemic Activity of a New Class of Squalene Epoxidase Inhibitors.

J.-P. GOTTELAND, I. BRUNEL, F. GENDRE, J. DESIRE, A. DELHON, D. JUNQUERO, P. OMS, S. HALAZY

Journal:

Année:

1995

Fichier:

PDF, 36 KB

1995

43

ChemInform Abstract: Synthesis and Serotonergic Activity of Arylpiperazide Derivatives of Serotonin: Potent Agonists for 5-HT1D Receptors.

M. PEREZ, C. FOURRIER, I. SIGOGNEAU, P. J. PAUWELS, C. PALMIER, G. W. JOHN, J.-P. VALENTIN, S. HALAZY

Journal:

Année:

1995

Fichier:

PDF, 36 KB

1995

44

ChemInform Abstract: An Efficient Approach to the Synthesis of a Key Precursor of Mammalian Squalene Epoxidase Inhibitors Using a New Method for Transforming Aryl Bromides to Phenols.

J.-P. GOTTELAND, S. HALAZY

Journal:

Année:

1996

Fichier:

PDF, 30 KB

1996

45

ChemInform Abstract: Fluorophosphonate Derivatives of N9-Benzylguanine as Potent, Slow- Binding Multisubstrate Analogue Inhibitors of Purine Nucleoside Phosphorylase.

S. HALAZY, A. EHRHARD, A. EGGENSPILLER, V. BERGES-GROSS, C. DANZIN

Journal:

Année:

1996

Fichier:

PDF, 30 KB

1996

46

ChemInform Abstract: Synthesis and Structure-Activity Relationships of 5-Substituted Tryptamine Derivatives of o-Tolylpiperazine as Agonists at 5-HT1D Receptors.

M. PEREZ, P. J. PAUWELS, C. PALMIER, G. W. JOHN, J. P. VALENTIN, S. HALAZY

Journal:

Année:

1996

Fichier:

PDF, 32 KB

1996

47

ChemInform Abstract: Synthesis, Enzymatic Phosphorylation and Antiviral Activity of Acyclic Dienyl Phosphonate Derivatives of Guanine.

J.-F. NAVE, P. J. CASARA, D. L. TAYLOR, A. S. TYMS, M. KENNY, S. HALAZY

Journal:

Année:

1996

Fichier:

PDF, 29 KB

1996

48

ChemInform Abstract: Design and Synthesis of New Hypocholesterolemic Organosilanes with Antioxidant Properties.

J.-P. GOTTELAND, A. DELHON, D. JUNQUERO, P. OMS, S. HALAZY

Journal:

Année:

1996

Fichier:

PDF, 33 KB

1996

49

ChemInform Abstract: A Simple One-Pot Preparation of N,N′-Unsymmetrical Ureas from N-Boc Protected Primary Anilines and Amines.

M. LAMOTHE, M. PEREZ, V. COLOVRAY-GOTTELAND, S. HALAZY

Journal:

Année:

1996

Fichier:

PDF, 29 KB

1996

50

ChemInform Abstract: Inhibition of Farnesyl Protein Transferase by New Farnesyl Phosphonate Derivatives of Phenylalanine.

M. LAMOTHE, D. PERRIN, D. BLOTIERES, M. LEBORGNE, S. GRAS, D. BONNET, B. T. HILL, S. HALAZY

Journal:

Année:

1996

Fichier:

PDF, 28 KB

1996